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Africa: Antiretroviral Microbicides Enter Clinical Trials

Cape Town — 'Next generation' microbicides containing antiretroviral drugs (ARVs) are in early clinical testing and may hold out the best hope of protecting women from HIV/AIDS, a conference has heard.

Previous trials of nonspecific microbicides - gels containing general antimicrobial agents - have been disappointing, say researchers, with only one product, PRO 2000, still under development (see Microbicide hope at last, say researchers). Results of a phase III trial of PRO 2000 are expected later this year.

Vaginal gels or rings containing HIV-targeting drugs are entering phase I and II trials coordinated by the International Partnership for Microbicides (IPM) and the Microbicide Trials Network (MTN), a non-profit collaboration between developed- and developing-world researchers that is funded by the US National Institutes of Health.

These topical ARVs are intended to inhibit HIV infection by blocking the virus from replicating in the cells it initially infects. Gels would need to be applied before sex, but a vaginal ring could provide protection from unanticipated sex.

Zeda Rosenberg, the IPM's chief executive, told a press conference at the 5th International AIDS Society (IAS) conference in Cape Town, South Africa, this week (21 July) that the trials are investigating how acceptable the different approaches are, as well as their effectiveness.

"Ideally we can develop several effective formulations - gels, tablets or rings - so that women can choose," she said.

MTN's large-scale, five-arm VOICE study will compare a gel containing the antiretroviral tenofovir with a placebo gel, tenofovir tablets, tablets containing both tenofovir and emtricitabine, another antiretroviral and placebo tablets for HIV prevention in southern African women. Recruitment of 5,000 women began this month (July).

Other MTN trials cover rectal tenofovir gels for men and women, and the safety of tenofovir gels in pregnant women. An IPM phase I/II safety trial of gel containing the antiretroviral dapirivine is also in progress.

Women recruited to the trials receive counselling on safe sexual practices and a supply of condoms. Participants who acquire HIV during the trials are offered treatment and are invited to enrol in MTN0015, a long-term observational study.

Most women who take part in the trials say they find them empowering. Women are finding it easier to communicate within relationships about safe sex and condom use after entering the trials," says Sheena McCormack, a clinical epidemiologist at the UK Medical Research Council's Microbicides Development Programme who is involved in PRO 2000 trials.

A marketable microbicide is still several years away, however, as further trials of efficacy and safety are needed. The trials must also address concerns that HIV may become resistant to these drugs.

Tagged: Africa, AIDS, Health, Science

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  • upliftdarace_144
    Jul 27 2009, 03:47

    Wake Up Black Africans They ( D-Evil ) Want Us Dead !

    They Want Our Resources !

    They are being used like puppets by D - Evil !

    HIV Aids - INVENTING THE AIDS VIRUS BY DR. PETER DUESBERG In his book he states that the so-called drug AZT was developed to kill T-Cells. T-Cells are what our bones need to make marrow.

    Don't buy the hype..there is no AIDS!!!

    PETER DUESBERG [ http://hiv-aids-factorfraud.com/ ] #2306 – “THE AIDS MAVERICK” via Tony Brown’s Journal

    YOU TUBE VIDEO ON VACCINATIONS & THE MARK OF THE BEAST [ http://www.youtube.com/watch?v=NOOn_HXy5MQ ]

    REVELATIONS 13:18 Here is wisdom. Let him that hath understanding count ( Compute) the number of the beast: for it is the number of a man; and his number is Six hundred threescore and six.

    Take The Word “ V-A-C-C-I-N-A-T-I-O-N “ Letter-By-Letter • Multiply Each Letter’s Numerical Value By 6. • Then Add All the Totals Together What Do You Get ? • V (22nd letter times 6 = 132) – A (1st letter times 6 = 6) – C (3rd letter times 6 = 18) – C (3rd letter times 6 = 18) I (9th letter times 6 = 54) – N (14th letter times 6 = 84) A (1st letter times 6 = 6) - T (20th letter times 6 = 120) I (9th letter times 6 = 54) – O (15th letter times 6 = 90) N (14th letter times 6 = 84)

    Six-Hundred & Sixty-Six (666)

    REVELATIONS 13:18 Here is wisdom. Let him that hath understanding count ( Compute) the number of the beast: for it is the number of a man; and his number is Six hundred threescore and six.

    Virologist Dr. Peter Duesberg emerged as one of the scientific community’s brightest talents when he discovered the viral gene that can cause cancer. This program examines his research and his controversial stance on AIDS that nearly destroyed his career

    Medical Genocide Slow & Hidden.

    Check Out This Directive : Called The Georgia GuideStones

    [The Agenda Of The Antichrist aka The Georgia Guidestones] 10 POINTS LIKE THE 10 HORNS OR RELIGIONS OF THE BEAST

    1) MAINTAIN HUMANITY'S POPULATION UNDER 500 MILLION IN PERPETUAL BALANCE WITH NATURE

    2) GUIDE REPRODUCTION WISELY —IMPROVING FITNESS AND DIVERSITY

    3) UNITE HUMANITY WITH A LIVING NEW LANGUAGE

    4) RULE PASSION — FAITH — TRADITION AND ALL THINGS WITH TEMPERED REASON

    5) PROTECT PEOPLE AND NATIONS WITH FAIR LAWS AND JUST COURTS

    6) LET ALL NATIONS RULE INTERNALLY RESOLVING EXTERNAL DISPUTES IN A WORLD COURT

    7) AVOID PETTY LAWS AND USELESS OFFICIALS

    8) BALANCE PERSONAL RIGHTS WITH SOCIAL DUTIES.

    9) PRIZE TRUTH — BEAUTY — LOVE — SEEKING HARMONY WITH THE INFINITE

    10) BE NOT A CANCER ON THE EARTH — LEAVE ROOM FOR NATURE — LEAVE ROOM FOR NATURE

    #2- Here is evidence of Point 2 of the Georgia Guidestones on Reproduction .

    Don't be deceived : [http://www.infowars.com/?p=7259]

    Don't Go Here If You Like The Dark [http://www.infowars.com/infowars.asx]

    Jesus Christ said “ Except those days (of tribulation) be shortened , no flesh should be save “. There are sinister forces at work, especially in Black Africa, trying to destroy us by HOOK or CROOK.

    BY HOOK - Dr. Boyd E. Graves discovered the existence of a U.S. government- manufactured killing virus designed to kill Black People. It is called AIDS.

    1. This manufactured AIDS has a cure that the persons who developed it hold the patent on.

    2. Just Search using Dr. Boyd E Graves as a search word.

    BY CROOK – Dr. Peter Duesberg discovered that another form of AIDS was actually old diseases like pneumonia ( and other common diseases) which was renamed AIDS.

    1. This so-called form of AIDS actually doesn’t exist.

    2. But since the persons falsely-diagnosed to have this imaginary form of AIDS are treated with drugs like AZT , they tend to die from. The treatment.

    3. AZT was developed in 1958. It was developed to kill T-cells ; our source of life (the marrow in our bones ).

    4. Also Search using Dr.Peter Duesberg , author of “Inventing The Aids Virus “

    SO BEWARE OF THE AIDS GAME WITH YOUR LIFE AT STAKE.

    And in the LAST DAYS, when sin is running rampant in the land, a FIERCE-LOOKING WISE KING shall come into power.

    And his power shall be mighty. However The power he will have WILL NOT BE HIS OWN POWER.

    And THROUGH HIS POLICY HE SHALL CAUSE WITCHCRAFT TO PROSPER.

    And he shall magnify himself AND BY PEACE SHALL HE DESTROY MANY.

    He shall also stand up againt Jesus Christ, but HE SHALL BE DESTROY by the brightness of Christ’s return.

    [ http://www.youtube.com/results?search_type=&search_query=Peter+Duesberg&aq= f ]

    Many Of You Are Fulfilling Prophecy In A Sad, Foolish, Naïve Way. REVELATIONS 18 :23 And the light of a candle shall shine no more at all in you; and the voice of the bridegroom and of the bride shall be heard no more at all in you: for your merchants were the great men of the earth; for by your SORCERIES were all nations TRICKED .. AZT is the star of the AIDS death show..and many doctors are being tricked and bribed by the $$$$ !!!!

    THE AIDS HOAX PART 1- MUST SEE

    Embed [ ]

    URL [ http://www.youtube.com/watch?v=iW-gp41Q_PM ]

    THE AIDS HOAX PART 2- MUST SEE

    Embed [ ]

    URL [ http://www.youtube.com/watch?v=WZcDJlq_eiM ]

    THE AIDS HOAX PART 3- MUST SEE

    Embed [ ]

    URL [ http://www.youtube.com/watch?v=ZR8t2xcfuuU ]

    THE AIDS HOAX PART 4- MUST SEE

    Embed [ ]

    URL [ http://www.youtube.com/watch?v=IoYM-yhUObE ]

    THE AIDS HOAX PART 5- MUST SEE

    Embed [ ]

    URL [ http://www.youtube.com/watch?v=FFXKUlaiJ7M ]

    THE AIDS HOAX PART 6- MUST SEE

    Embed [ ]

    URL [ http://www.youtube.com/watch?v=bM86PYMQIbc ]

    THE AIDS HOAX PART 7- MUST SEE

    Embed [ ]

    URL [ http://www.youtube.com/watch?v=nfKk5CTdZpI ]

    THE AIDS HOAX PART 8- MUST SEE

    Embed [ ]

    URL [ http://www.youtube.com/watch?v=r_ED2jNgrQw ]

    Many Of You Are Fulfilling Prophecy In A Sad, Foolish, Naïve Way. REVELATIONS 18 :23 And the light of a candle shall shine no more at all in you; and the voice of the bridegroom and of the bride shall be heard no more at all in you: for your merchants were the great men of the earth; for by your SORCERIES were all nations TRICKED .. AZT is the star of the AIDS death show..and many doctors are being tricked and bribed by the $$$$ !!!!

    THE AIDS HOAX PART 9- MUST SEE

    Embed [ ]

    URL [ http://www.youtube.com/watch?v=wfC4hHxWKYE ]

    THE AIDS HOAX PART 10- MUST SEE

    Embed [ ]

    URL [ http://www.youtube.com/watch?v=mypiieJ4pP4 ]

    THE AIDS HOAX PART 11- MUST SEE

    Embed [ ]

    URL [ http://www.youtube.com/watch?v=_7W8CZvM6G0 ]

    THE AIDS HOAX PART 12- MUST SEE

    Embed [ ]

    URL [ http://www.youtube.com/watch?v=-LwMM8G8Iyo ]

    THE AIDS HOAX PART 13- MUST SEE

    Embed [ ]

    URL [ http://www.youtube.com/watch?v=ebpTSM17Mg4 ]

    *************************************************************************** *************************************************************************** *************************************************************************** *************************************************************************** ************************************************************ Many Of You Are Fulfilling Prophecy In A Sad, Foolish, Naïve Way. REVELATIONS 18 :23 And the light of a candle shall shine no more at all in you; and the voice of the bridegroom and of the bride shall be heard no more at all in you: for your merchants were the great men of the earth; for by your SORCERIES were all nations TRICKED .. AZT is the star of the AIDS death show..and many doctors are being tricked and bribed by the $$$$ !!!!

    Peter Duesberg: science vs."hiv/aids"

    [ Peter Duesberg On AIDS Hoax ]

    Embed [ ]

    URL [ http://www.youtube.com/watch?v=h5xZ4_aFHII ]

    The HIV Virus AIDS Lie - HIV DOES NOT CAUSE AIDS

    Embed [ ]

    URL [ http://www.youtube.com/watch?v=ST_DJmoyhNg ]

    The military-medical complex : Starring AIDS Co-Starring CANCER

    Embed [ ]

    URL [ http://www.youtube.com/watch?v=jXmJPfzwBOI ]

    [WHO'S AFRAID OF BEING THEMSELVES ALL THE TIME ? ]

    [This inspiring poem was featuring in the movie “Coach Carter ”]

    Our Deepest Fear Is Not That We Are Inadequate, Our Deepest Fear Is That We Are Powerful Beyond Measure. It Is Our Light , Not Our Darkness That Most Frightens Us.

    We Ask Ourselves, Who Am I To Be Brilliant, Gorgeous, Talented, And Fabulous ?

    Actually Who Are We Not To Be ? You Are A Child Of God.

    Your Playing Small Doesn’t Serve The World.

    There Is Nothing Enlightened About Shrinking So That Other People Won’t Feel Insecure Around You.

    We Are All Meant To Shine, As Children Do.

    We Were Born To Make Manifest The Glory Of God That Is Within Us.

    It’s Not Just In Some Of Us; It’s In Everyone.

    And When We Let Our Own Light Shine We Unconsciously Give Other People Permission To Do The Same.

    And As We Are Liberated From Our Own Fear, Our Presence Automatically Liberates Others

    - Marianne Williamson -

    [NOTE – BEING AFRAID AND REFUSING TO GET INVOLVED WON’T STOP US FROM DYING. BUT BEING AFRAID CAN PREVENT US FROM LIVING]

    (Nkosi Sikeleli Africa )

    God bless Africa May her glory be lifted high Hear our petitions .

    God bless us, Your children God we ask You to protect our nation Intervene and end all conflicts Protect us, protect our nation, our nation.

    From the blue of our heaven, From the depths of our sea, Over our eternal mountain ranges, Where the cliffs give answer.

    Sounds the call to come together, And united we shall stand, Let us live and strive for freedom, In South Africa our land.

    [Enoch Mankayi Sontonga]

    WAKE UP !!! STAY UP !!!

    [http://www.infowars.com/infowars.asx] / [gcnlive.com] / [http://alexjonesringtones.net/] Life Is A Game. Have Fun . Luke 18:17 - Isaiah 11:6