The Super Eagles and the Wasps of Rwanda will compete for a place in the final round of the South Africa 2013 qualification this Saturday at the UJ Esuene Stadium.
In the reverse game of this first round clash, both teams played out a 0-0 draw at the Stade Amahoro in Kigali on February 29.
Rwanda, ranked 119 by the world soccer governing body, FIFA, have failed to win in their last five matches.
The Wasps go into this game with a heavy 0-4 defeat at Algeria and a 1-1 draw at home to Benin Republic in the 2014 FIFA World Cup qualifying.
Milutin Sredojevic's men come up against the Super Eagles, who have taken four points in their opening two games in the World Cup qualification this June.
But the Eagles under Stephen Keshi have averaged less than a goal per game in their last three competitive matches.
Keshi has expressed concern about his team's approach in the final third.
"We have been working on our finishing in training because that has been an area this team have not been prolific. Hopefully tomorrow (Saturday) will be different," said Keshi to SuperSport.com.
For this game, Keshi has left out Dickson Etuhu, Peter Osaze Odemwingie, Joel Obi, Taye Taiwo and Yakubu Aiyegbeni, who all started in the first clash in Kigali as well as injured captain Joseph Yobo.
However, Sredojevic has named a strong Rwandan side of 18 players that include influential captain and striker, Olivier Karekezi, Bokota Labama, Steven Godfroid and goalkeeper Jean Claude Ndoli.
The Wasps have never beaten their Nigerian counterparts as the West Africans have won once and drawn twice in their last three head-to-head meetings.