In a renewed hope to eliminate the menace of malaria on human health, researchers at the Johns Hopkins Malaria Research Institute have genetically modified a bacterium commonly found in the mosquito's midgut, to kill the malaria parasite before it is transmitted.
The bacterium, Pantoea agglomerans, was modified to secrete proteins toxic to the malaria parasite, but the toxins do not harm the mosquito or humans. According to a study published by PNAS, the modified bacteria were 98 percent effective in reducing the malaria parasite burden in mosquitoes.
Dr. Marcelo Jacobs-Lorena, Senior author of the study and a professor with Johns Hopkins Bloomberg School of Public Health said: "In the past, we worked to genetically modify the mosquito to resist malaria, but genetic modification of bacteria is a simpler approach. The ultimate goal is to completely prevent the mosquito from spreading the malaria parasite to people."
With the study, Jacobs-Lorena and his colleagues found that the engineered P. agglomerans strains inhibited development of the deadliest human malaria parasite Plasmodium falciparum and rodent malaria parasite Plasmodium berghei by up to 98 percent within the mosquito. The proportion of mosquitoes carrying parasites (prevalence) decreased by up to 84 percent.
"We demonstrate the use of an engineered symbiotic bacterium to interfere with the development of P. falciparum in the mosquito. These findings provide the foundation the use of genetically modified symbiotic bacteria as a powerful tool to combat malaria," said Jacobs-Lorena.