Nigeria's Premier League champions Kano Pillars will face Olympique de Bangui from Central African Republic in the preliminaries of the 2013 CAF Champions League.
Nigeria's other representatives Rangers, who finished as runners-up to Pillars, will battle SC Do Principe of Sao Tome and Principe, also in the prelims of the competition.
Both teams will first host their opponents between February 15 and 17 with the return leg clash fixed for between March 1-3.
Nigeria's Sunshine Stars reached the semi-finals of this year's competition before they were eliminated by eventual champions Al Ahly of Egypt.
Enyimba are the only Nigerian club to have won this competition, having won it back-to-back in 2003 and 2004.
In the second-tier CAF Confederation Cup, both Lobi Stars and Heartland are drawn bye till the Round of 16.
Lobi will take on the winners of the clash with Botswana's Gaborone and Muculmana from Mozambique, while Heartland face the winners of the preliminary round fixture between D.D Guadulupe of Sao Tome and principle and Bitam from Gabon.
The first legs of these matches are fixed for between March 15 to 17 with the second legs to be played between April 5 to 7.
No Nigerian club have yet won this competition.