Kenya champions Tusker succumbed 2-1 to African champions Al-Ahly in the first leg, first round match of the Caf Champions League at Nyayo Stadium on Saturday.
The result means that the brewers must win the return match by two clear goals to be assured of making it to the next round when the two sides clash again after a fornight.
Substitute Ahmed Shokry scored both goals for the visitors in the second half. His first goal came in the 48th minute placing the ball past Boniface Oluoch in goal.
In a move that caught the Tusker defense napping, Mohammed Barakat found Shokry with a short corner which was quickly returned to him creating space for the goal scorer to hit the back of the net.
Eight minutes later, Barakat turned provider again and allowed Shokry to score his second from a header that once again exposed the Tusker defense.
Tusker's goal was netted by Jesse Were in the 59th minute after he headed home a Robert Omunik cross.
Coming into Saturday's match, Tusker showed a lot of determination and had forced a corner on kick-off. It took about ten minutes for the visitors to settle and when they did, the forced a corner in the 11th minute.
Tusker's first effort at goal came in the 17th minute with impressive Ugandan import finding himself unmarked in the Al-Ahly defense.
His effort was just put out by Ahmed Kenani who used his hand to keep the ball out but match referee Nhleko Simanga from Swaziland waved play on.
Seven minutes later as Tusker piled pressure Luke Ochieng's goal bound effort was put out for a fruitless corner.
As the half hour mark approached, Were should have put Tusker ahead but was stopped by Sherif Elkramy for another fruitless corner.
Tusker then rested Ismael Dunga for teenage striker Michael Olunga in a move that brought some lively moments upfront. The former Upper Hill High School student, should have tapped home a Robert Omunik cross minutes after he came on but was too slow on the ball.
Three other clear chances by the brewers went begging as the second half wore on and coach Robert Matano admitted it will be a tall order for his side in the return match.
"We did not have the required concentration at the back and our players were wasteful in front of goal. This all boils down to inexperience. We will continue working on this to ensure we get something positive in the return leg away," he said.
Tusker must win by at least two clear goals to be sure of progressing to the second round. Gor Mahia the other Kenyan club in continental football, lost 3-0 on Friday to another Egyptian side ENPPI.