Egyptian giants, Al-Ahly and Ivorian side, Sewe Sport booked their places at the last four during the final day matches of Group B on Saturday.
A barren draw against Etoile du Sahel of Tunisia in Cairo was enough to send the 'Red Devils' into the next phase of the second-tier continental club championship whilst Sewe Sport inked their place thanks to a 3-0 thrashing of Zambian champions, Nkana in Abidjan.
Ahly, record eight-time winners of the prestigious CAF Champions League, finished on nine points, same as Sewe Sport, but with the upperhand via head-to-head. Nkana managed seven points with Etoile in that order on six points.
Ahly were lucky to escape with a point against an Etoile side that had the better of possession throughout the game despite finishing with 10-men after Cameroon-import Franck Kom was sent off in the dying stages for an off-the-ball foul on Ahly midfielder Amr Gamal.
The Egyptians survived several onslaughts into their half by the visitors, who needed nothing but the maximum points to topple their hosts into the last four.
Elsewhere, Sewe Sport were too much for Zambia's Nkana, who could have gone through by avoiding defeat. Kouao Herman broke the deadlock on nine minutes, Joseph Kameni doubled the lead three minutes from recess before dangerman Roger Assale completed the rout on 73 minutes.
Ahly will face the runner-up in Group A at the semis whilst Sewe Sport squares the winner of the group.
Cameroonian champions, Coton Sport have already qualified from Group A with other slot to be decided between AC Leopards of Congo and AS Real of Mali.