VICE PRESIDENT Emmerson Mnangagwa Wednesday morning claimed that suspects drilled a ceiling panel to gain entry into his office making the burglary the fourth to have happened in the same office.
Justice, legal and parliamentary affairs permanent secretary Virgina Mabhiza told the state media that the break-in was discovered by Mnangagwa on Wednesday around 7am.
Officials from the Radiation Protection Authority of Zimbabwe were said to be busy doing their investigations at the office.
However Mabhiza said there was no clue yet if anything was stolen and if the intention of the break-in was to "insert anything". She however said there were "visible holes" on the ceiling.
Information minister Christopher Mushowe said the pattern will suggest that the people who did the break-in were familiar with the "nature of the panels" at VP's office.
Mushowe said government was "concerned" and was not going "to allow this to continue to happen". In one of the 'break-ins' in 2014, cyanide was sprinkled inside Mnangagwa's office.
Last year, his Mercedes car was hit by another vehicle in Harare.
Mnangagwa took over as acting president from Phelekezela Mphoko Monday. He is seen as one of the Mugabe's trusted men with a chance of taking over. He is, however, facing resistance from the so-called G40 with is said to prefer Grace Mugabe as her husband's successor.
The G40 group is said to include local government minister, Savior Kasukuwere, information minister Jonathan Moyo and Mugabe's nephew Patrick Zhuwao.
Mnangagwa was the minister of state security in the 1980s when government targeted civilians in the "hunt for the dissidents" in Matabeleland and the midlands.
However, recently released documents from South Africa have shown that he routinely exaggerated the extent of the dissidence problem, at some time parading boys before the national TV whom he claimed were sent by apartheid South Africa to destabilise Zimbabwe.
Evidence has also emerged from declassified documents that he had a working relationship with apartheid Pretoria.
In 2010, Mnangagwa was named by Genocide Watch as one of the chief culprits in the 1980s killings.