Another school could be on the cards for the North West province as well.
Nelson Mandela University (NMU) will open South Africa's ninth medical school in 2020 when the school is expected to accept its first class of 100 aspiring doctors.
In a move greenlighted by Higher Education Minister Blade Nzimande last year, the Port Elizabeth university will expand its existing health science faculty to include an undergraduate medical degree, says NMU spokesperson Zandile Mbabela.
The school will eventually offer specialist training in fields such as radiography and emergency medical care, she says.
The faculty currently offers qualifications in psychology, nursing, social work, pharmacy and human movement sciences. By 2030, the university aims to train 200 new doctors each year, Mbabela explains.
Experts are optimistic that the new project will help to address the Eastern Cape's scarcity of doctors. Until now, Walter Sisulu University was the only school producing physicians in the province.
And with another medical school on the horizon, South Africa could also begin reducing its national shortage of doctors. The country has less than one such medical professional for every 1 000 citizens, according to 2015 World Bank data.
North-West University has also applied to open a new medical school at their Potchefstroom campus. Spokesperson Louis Jacobs says the university expects to know whether the application has been approved by the departments of health and higher education and training by the end of the year.
Meanwhile, the University of the Free State is planning to partner with Sol Plaatjie University and hospitals in Kimberley to increase its intake of medical students, says president of the Public Health Association of South Africa André Rose.
A community health worker from the nonprofit Philani Mentor Mother Programme visits a woman in the rural Eastern Cape. Rural areas need more heath workers - could more medical schools be the answer?
In Port Elizabeth, South Africa's newest medical school is also expected to pioneer novel ways of learning.
NMU's medical students will receive "decentralised" training, dividing their time between working in primary healthcare clinics and lectures - many of which may be online.
South African medical students already spend time in health facilities as part of their studies but much of this happens in large academic hospitals. These facilities often specialise in seeing complicated cases and don't treat the more common, everyday ailments that South Africans live with, explains Ian Couper, director of Stellenbosch University's Ukwanda Rural Clinical School.
"Patients who land up in big teaching hospitals have more complex health issues, not the ongoing problems like HIV, which they have to deal with on a daily basis," he says.
To better equip students for rural settings, Ukwanda already uses a form of decentralised training, sending students to rural hospitals for their final year.
Couper adds that, globally, many medical students are moving towards online curriculums that can make decentralised and online training easier.
"Historically, medical schools were centred around big academic hospitals as a way of standardising practice but now we are far more connected.
"Medicine shouldn't be taught in big classrooms. The best way to learn is in small groups that are practically focused," he says.
And getting students out of the classroom and into clinics can be better for them and communities.
Research conducted by Couper and others in 11 African countries, including South Africa, found that medical students improve the quality of care at health facilities, he says.
"We found the students increase the time and attention given to patients as well as the atmosphere of learning at the facility."
The research, which has been repeated at sites in Stellenbosch, will be published in Academic Medicine journal.
"Nelson Mandela University could become the shining light for the return of rural doctors in South Africa and the continent," Rose says.
A woman walks in the rural Eastern Cape. What is the greatest predictor of whether doctors choose to practice in rural areas? If they were born there. (Madelene Cronjé, MG)
But if South African medical schools are looking for graduates to work where they are needed most, they are going to have to prioritise admissions for rural students, warns Couper.
Growing up in a rural area is the most important factor associated with doctors deciding to return to communities such as these to practice, a 2009 review by the Cochrane research network found.
Couper says: "There's no absolute guarantee rural students will become rural doctors, but there is a likelihood."
And students who are trained in a rural setting are also more likely to practice in a rural setting, revealed a 2007 article published in the South African Medical Journal.
But Couper cautions that universities such as NMU will have to invest resources into making new and rural decentralised models of learning work. He believes NMU can do this.
He explains: "The students will need connectivity, accommodation and a space to reflect on their studies with a supervisor. Supervisors will have to be trained. You can't assume people will naturally slot into the role because they are health professionals.
"Training in the field is different from everyone just sitting in a lecture hall."
Have something to say? Tweet or Facebook us on @Bhekisisa_MG