Quinton de Kock and JP Duminy have been announced as the respective stand-in captains for the remainder of the One-Day International (ODI) series and one-off T20 International (T20I) against Sri Lanka.
De Kock will take the reins for the last two ODI's taking place in Kandy and Colombo, while Duminy will lead the tour closing T20I in Colombo.
This is De Kock's first stint in a leadership position within the Proteas setup - he captained SA U19 in 2012 - a decision head coach, Ottis Gibson, believes will help grow the leadership group within the environment.
"I have always found Quinton to have a good cricket brain, he understands the game," he said in Kandy on Tuesday.
"With Faf injured, it seems like a good opportunity and chance for him to show that side of his game as a leader for the next two games. He is someone who understands the game, he is constantly helping the captain on the field, he shows good leadership on the field even as a normal player.
"It is about trying to grow the team and growing the leaders within the team," he explained.
"Aiden captained against India and he is not currently in the team, he has had some struggles on this Sri Lanka tour so far. We thought we would have a look at Quinton for the next two games, which will give Aiden time to settle himself. He is a fine player and we are confident he will find form and there will be other opportunities for us to continue to grow that side of his leadership."
Duminy captained the T20I team in Du Plessis' absence during the three-match series against India at home earlier this season, and returns to lead the group for the one-off match next Tuesday.
"For the last while when Faf was rested or injured JP has been the T20 captain," Gibson explained.
"He has done a good job with that, leadership in the T20 format has brought the best out of him so that is something we will continue with."
The Proteas have an unassailable 3-0 lead in the series, and have turned their tour around after the disappointing 2-0 loss in the Test series. De Kock says he is excited for this next chapter and will aim to continue with the legacy introduced by Du Plessis.
"To be honest, I am feeling quite nervous, it is an honour to be given this responsibility of captaining the Proteas," he said.
"I want to carry on where Faf has left off and to continue with his legacy. As a captain, I will try to stay true to myself and stay true to what I believe it takes to be a good leader. I will strive to help others going forward, just to be there as a captain.
"The team performance at the moment speaks for itself," he said the 3-0 lead.
"Everybody is doing something right at the moment. Everyone is chipping in, the batsmen are scoring runs, the bowlers are taking wickets and the fielding has been on top. We will try to keep the standard of cricket that we have going for the next two ODI's."
The fourth ODI against Sri Lanka takes place at Pallekele on Wednesday. The match is scheduled to start at 11:00 (SA time).