Africa: MSF Calls on US Pharma Corporation Johnson & Johnson to Cut Key TB Drug Price in Half

Simbongile Xesha collects her medication from the pharmacy at Town 2 Clinic, Kuyasa, Khayelitsha.
press release

People with drug-resistant tuberculosis (DR-TB) continue to be deprived of today’s best-possible treatment in part because of high drug prices, according to a new report - DR-TB Drugs Under the Microscope - released today by Doctors Without Borders (MSF) at the 49th Union World Conference on Lung Health in The Hague.

MSF called, in particular, on US pharmaceutical corporation Johnson & Johnson (J&J) to cut the price of the newer TB drug bedaquiline in half, so more lives can be saved.

In August 2018, the World Health Organization (WHO) recommended expanding use of bedaquiline (produced by J&J) by making it a core drug for treatment of DR-TB, while at the same time relegating drugs that need to be injected daily - and can cause deafness, renal failures and other severe side effects—to last-resort options only.

This change dramatically increases the number of people who should receive bedaquiline, and requires national TB treatment programmes to scale it up as part of the DR-TB treatment they provide. Despite the expected benefits, high prices remain a significant barrier.

MSF’s research shows that DR-TB treatment regimens containing the two newer drugs bedaquiline and delamanid represent a significant price increase over older, no-longer-recommended treatment regimens.

People with DR-TB must receive individually tailored treatment consisting of at least five drugs for different durations, according to the type of drug-resistant TB that affects them.

The estimated price of longer individualized treatment regimens could now reach more than US$2,000 for people who need at least 18 months of bedaquiline, which would represent a 50% price increase over previous standard treatment.

People who might need both bedaquiline and delamanid for as long as 20 months, the price increase could reach 500%, with a treatment regimen priced at around $9,000.

“Our analysis clearly shows that the high price of the two newer TB drugs makes today’s best-possible treatment much more expensive than previous treatment regimens,” said Sharonann Lynch, HIV & TB advisor for MSF’s Access Campaign.

“These newer TB drugs will save more lives, benefit programmes and make this arduous treatment more tolerable for people, but if they remain priced out of reach, they will not serve their purpose and the expected gains will not be achieved. Unless pharmaceutical corporations lower their prices substantially, people will continue to suffer without access to safer and more effective treatment.”

J&J recently announced a price reduction for bedaquiline for some countries, but this falls short of making the drug affordable in countries hardest hit by the DR-TB epidemic.

Its price of $400 for six months of treatment is still too high, as many people need the drug for significantly longer than six months, driving the price even higher.

J&J received substantial taxpayer money from the US and other governments for the development of bedaquiline, and therefore has a clear responsibility to make sure the public gets a return on this investment by making the drug affordable for everyone who needs it.

To ensure the drug is accessible to all, MSF called on J&J to issue a non-exclusive license to the Medicines Patent Pool to allow for price-lowering competition among generic producers.

“The new treatment recommendations from WHO represent the best chance for a cure with fewer debilitating side effects for people with drug-resistant TB,” said Dr. Naira Khachatryan, Medical Coordinator of MSF’s project in Armenia.

“If bedaquiline continues to be too expensive, countries will have limited opportunity to scale up treatment, and we’ll be stuck with the deadly status quo where the majority of affected people will not have a chance to benefit from more effective treatment.”

An estimated 558,000 people developed DR-TB in 2017, but only 25% of those estimated cases were treated.

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