Former Zanu PF Politburo member Ms Cleveria Chizema was yesterday fired for seeking to foment dissent in ZANU PF.
Ms Chizema was shown the door together with Mr Tendai Savanhu.
Addressing the Politburo meeting, President Mnangagwa said Ms Chizema, who was on suspension, could no longer continue to be a member of the party because of her conduct.
"Politburo will recall that during the last session, we received a preliminary security report on the acts of disloyalty by Cde Chizema.
"I have since gone through the detailed final security report, which reveals gross and glaring acts of disloyalty and treachery by Cde Chizema.
"As such, Cde Chizema can no longer continue to be a member of the party," he said.
Ms Chizema was suspended by the party at the last Politburo meeting after the security department presented a report on how internal forces were fomenting discord in the party.
Addressing the media soon after the 343 session of the Politburo, Zanu PF acting spokesperson Cde Patrick Chinamasa said the duo of Ms Chizema and Mr Savanhu joined former Youth League member Tinashe Maduza who was expelled from the revolutionary party early this month.
"The Politburo unanimously decided that Mrs Cleveria Chizema be fired from the party because of the seriousness of her case, in which she did not deny any wrongdoing.
"She joins her accomplice, Tinashe Maduza who was expelled in the previous Politburo. The Politburo warned that any elements bent on or working to split our leadership and dividing the party will be treated with no leniency," Cde Chinamasa said.
The Politburo also endorsed the suspension of former Youth Affairs chairman for Matabeleland North Province Mr Tamuka Nyoni whose province recommended for his expulsion on allegations of misconduct after he reportedly received money from the MDC-sponsored Tajamuka/Sesjikile to organise foiled July 31 protests.
Following the expulsion of Mrs Chizema, the Politburo appointed Dr David Parirenyatwa as the substantive Secretary for Health and Child Care with immediate effect, while Cde Richard Ndlovu is now a committee member in the Politburo.
On Harare and Bulawayo provinces, Cde Chinamasa said the President recommended that an interim committee, comprising of the top three cadres from each District Coordinating Committee (DCC) in the two provinces be appointed to lead the structures.
The three senior officials per DCC will be joined by war veterans, Youth League and Women's League representatives
Meanwhile, the Commissariat Department, led by the National Political Commissar Cde Victor Matemadanda, presented a report highlighting that the party was now gearing for restructuring in provinces with no structures.
"The Political Commissar also highlighted that the party grassroots were very enthusiastic and happy with the determination in which the President and Government were intensifying the fight against corruption in Central Government and local councils," Cde Chinamasa said.