A total of 26 165 COVID-19 tests were conducted on Tuesday, with 848 new cases, which represents a 3.2% positivity rate.
This means that the country now has 1 559 960 confirmed infections since the outbreak.
Meanwhile, 67 more people succumbed to the respiratory disease, pushing the tally to 53 423 to date.
According to Health Minister, Dr Zweli Mkhize, 28 fatalities were recorded in Gauteng, 19 from the North West, nine from the Free State, eight from the Eastern Cape, two from the Northern Cape and one from the Western Cape.
"We convey our condolences to the loved ones of the departed and thank the healthcare workers who treated them," said Mkhize.
In addition, the Minister announced that the country is now home to 21 222 active cases, while 485 315 beat COVID-19, bringing the recovery rate to 95%.
The information is based on the 10 181 143 tests of which 26 165 were completed in the last reporting cycle.
Mkhize said the number of vaccinated healthcare workers now stands at 292 623.
According to the World Health Organisation (WHO), there have been 136 291 755 confirmed global cases of COVID-19, including 2 941 128 deaths, to date.
Meanwhile, 732 981 684 vaccine doses have been administered as of 13 April 2021, the WHO reported.