At least six people have been shot dead in Kwanobuhle in Kariega, Nelson Mandela Bay.

On Tuesday night, three men stormed into a house in Kwanobuhle and opened fire instantly killing six people and wounding four others.

Police spokesperson, Colonel Priscilla Naidu, said that males were shot at the gate of the property while a further eight people were shot in the house, leaving five dead, and three others injured.

"The total number of deceased persons is five males and one female, while four males and a female were injured," he said.

Naidu said their names and ages are still to be determined and the motive for the massacre is unknown at this stage.

This latest mass killing follows five months after eight people were gunned down at a house in Kwazakhele during a birthday celebration.

In February, four students from a local TVET college were shot dead when three gunmen fired shots at a house in Kwazakhele.

Eastern Cape provincial commissioner, Lieutenant-General Nomthethelele Mene has condemned the senseless killing and has called on the community to assist police in tracing the perpetrators.