Mr Buhari will return to Nigeria on Sunday.
President Muhammadu Buhari will depart Abuja on Wednesday for Kigali, Rwanda, to attend the 26th Commonwealth Heads of Government Meeting (CHOGM), being held from June 20 to 26.
The theme for CHOGM 2022 is, "Delivering a Common Future: Connecting, Innovating, Transforming."
The president's spokesman, Femi Adesina, confirmed this in a statement on Wednesday in Abuja.
According to Mr Adesina, the president will join other leaders in discussions on the progress and prosperity of the more than two billion people living in the 54 independent countries in Africa, Asia, the Americas, Europe and the Pacific that make up the Commonwealth.
"The Heads of Government are expected to reaffirm their commitment to upholding the Commonwealth Charter, which focuses on democracy, human rights, the rule of law, as well as economic opportunities and sustainable development," he said.
The Nigerian leader, according to the media aide, will attend the official opening ceremony on June 24, followed by high-level meetings of Heads of State and Government on Friday 24 and Saturday 25 June.
He said: "The leaders are expected to consider a range of topical issues including post COVID-19 economic recovery, debt sustainability, climate change, poverty reduction, youth entrepreneurship and employment, trade and food security.
"Prior to this, the Nigerian delegation drawn from the public, private and youth organisations participated in four forums covering youth, women, business and civil society; and will engage in ministerial meetings and several side events.
"On the margins of the meeting, the Nigerian leader is scheduled to deliver remarks at the High-Level Session of Malaria and Neglected Tropical Diseases Summit and participate in an Intergenerational Dialogue for Youth.
"President Buhari is also expected to hold bilateral talks with some leaders from the Commonwealth countries," he further stated.
The biennial meeting was due to take place in June 2020 but was postponed twice due to the COVID-19 pandemic.
Mr Buhari, in an article published in The Telegraph, London, stressed that the Commonwealth could become a real global power with improved collaborations on trade and security, lending weight to each other in international bodies.
The president will be accompanied by the Minister of Foreign Affairs, Geoffrey Onyeama; the Minister of Finance, Budget and National Planning, Zainab Ahmed; the Minister of Health, Osagie Ehanire; the Minister of Environment, Mohammed Abdullahi and the Minister of Communications and Digital Economy, Isa Pantami.
Others in the president's entourage are the National Security Adviser, Babagana Monguno, Director-General, National Intelligence Agency (NIA), Ahmed Rufa'i and the Chairman/CEO Nigerians in Diaspora Commission (NidCOM), Abike Dabiri-Erewa.
The president will return to the country on Sunday.