The strong development gains evident in many countries in southern Africa during the eighties and nineties are rapidly being reversed. The reason for this is largely due to the impact of HIV/AIDS. Indeed, the goals of sustainable development, the Millennium Development Goals, shared by national governments, United Nations, NGOs, civil society, communities and individuals, are under threat. Every effort is needed to help stop and reverse the current downward trend in human development indicators. This paper provides a strategic framework for humanitarian interventions geared to support these efforts.