Whilst in recent years there has been much investment from business, NGOs, international organizations and governments to tackle health problems such as HIV / AIDS, TB and Malaria in Africa, the weakness of the region’s healthcare systems – the infrastructures that organize, finance and ensure the quality of health services - means that much of the new funding is not used as efficiently as it could be. In the first ever project of its kind, the World Economic Forum’s Global Health Initiative has brought together a range of stakeholders to identify how business could partner with the public sector to improve healthcare systems in Sub-Saharan Africa. The resulting White Paper for consultation collects the views of diverse stakeholders on the barriers to effective healthcare systems in the region, and identifies opportunities for business to use its knowledge and skills to help tackle the problems through new public private partnerships. If turned into action some of the strategic interventions identified in this paper could contribute to improving access to health for millions of Africans.