This video highlights RTS,S, the world's most advanced malaria vaccine candidate, which is now in a Phase 3 clinical trial at 11 trial sites in seven African countries. The video discusses the history of the vaccine's development, including today's Phase 3 trial; the potential impact of a malaria vaccine; and the scientific background on how the vaccine works. It features footage of African trial sites and interviews with lead researchers in Africa, including the co-inventor of the vaccine, Dr. Joe Cohen, and the director of the PATH Malaria Vaccine Initiative, Dr. Christian Loucq.