Since the early days of the HIV epidemic, people have struggled against the odds and faced significant risks in pursuit of a more equitable world that supports their well-being. People with purpose and vision have led the HIV response, and their struggle has evolved into unprecedented national commitment. Recognizing the need to respond to the complex social, health and development challenges inherent in HIV, countries have adopted a multisectoral response to HIV that includes government ministries, civil society, people living with and affected by HIV, international development partners, United Nations agencies, faith-based communities and the private sector.