President Bola Tinubu had asked ministers and other political appointees seeking to contest in 2027 to resign from their current position.
The Minister of Foreign Affairs, Yusuf Tuggar, has resigned from his position.
Mr Tuggar's resignation was confirmed in a Facebook post by his spokesperson, AlKasim Abdulkadir.
PREMIUM TIMES had reported that Mr Tuggar would resign on Monday as he prepares to seek the APC ticket to be the governor of Bauchi State.
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President Bola Tinubu had asked ministers and other political appointees seeking to contest in 2027 to resign from their current positions by 31 March.
Mr Tuggar's resignation came a day before the deadline.
Mr Tuggar, who confirmed his resignation later on Monday, said his resignation letter was formally submitted to the president earlier that day through the Office of the Secretary of Government in Abuja.
"Today, I formally submitted my resignation letter as Nigeria's Minister of Foreign Affairs at the Office of the Secretary to the Government of the Federation, in line with the directive of President Bola Ahmed Tinubu, GCFR, and the provisions of the Electoral Act," he wrote.
He stated that the "moment marks the close of a significant chapter of his service," which, according to him, focused on improving global partnerships and diplomatic engagement.
He also said, "I express my sincere appreciation to President Tinubu @officialABAT for the trust and opportunity to serve under the Renewed Hope Agenda, and to contribute to advancing Nigeria's foreign policy through the 4D Doctrine.
"I express my sincere appreciation to President Tinubu @officialABAT for the trust and opportunity to serve under the Renewed Hope Agenda, and to contribute to advancing Nigeria's foreign policy through the 4D Doctrine."
Mr Tuggar is a former member of the House of Representatives. He was elected to represent the Gamawa Federal Constituency in 2007.
He also served as Nigeria's Ambassador to Germany from 2017 to 2023 under former President Muhammadu Buhari.