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Historic Africa-Led HIV Vaccine Trial Begins in South Africa

An African-led research initiative working to develop an HIV vaccine, under the aegis of The BRILLIANT Consortium, has launched the BRILLIANT 011 trial at the Desmond Tutu Health Foundation in Cape Town. The trial is being conducted by the South African Medical Research Council (SAMRC) and aims to tackle the specific strains of the virus circulating in Southern Africa.

With the first participant already enrolled, this groundbreaking initiative - launched in 2024 - unites leading researchers from South Africa, Nigeria, Uganda, Kenya, Tanzania, Zimbabwe, Zambia, and Mozambique.

"The trial is...marking a major milestone in African-led HIV vaccine research. BRILLIANT 011 brings renewed hope that an HIV vaccine developed through African science, for African populations, is becoming increasingly possible," the SAMRC said in a statement.

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The Global Fund for HIV, TB and Malaria says it will fund the roll-out of the twice-yearly anti-HIV jab, lenacapavir, for poorer countries, including South Africa, with or without the help of the US government's Aids fund, Pepfar.

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