The World health statistics report is the annual compilation of health and health-related indicators, which has been published by the World Health Organization (WHO) since 2005. The 2025 edition consists of four chapters and the accompanying annexes. Chapter 1 presents an indepth analysis of global and regional estimates of life expectancy, healthy life expectancy and progress in the reduction of premature mortality. Chapter 2 reviews the status of the health-related Sustainable Development Goal (SDG) indicators, covering age- and cause-specific mortality, infectious diseases, risk factors for health, and universal health coverage (UHC) and health systems. A summary of global and regional trends towards the achievement of selected health-related SDG indicators is further presented in Annex 1. Chapter 3 presents updated projections on WHO's Triple Billion targets, based on the most recent available data. It also describes WHO's transition from its thirteenth general programme of work (GPW13) to the fourteenth general programme of work (GPW14), aligning with emerging global health challenges and priorities. Chapter 4 looks at inequalities in immunization as an important global health issue. The information presented in World health statistics 2025 is based on data available from global monitoring as of April 2025. These data have been compiled primarily from publications and databases produced and maintained by WHO, other United Nations entities (such as UNICEF, UNAIDS, and the Population Division in the Department of Economic and Social Affairs of the United Nations), United Nations Inter-Agency bodies of which WHO is a member, and other international organizations. A summary of the methodology for each chapter is described in Annex 2. Tables of health statistics by country and area, WHO region and globally can be accessed via https://www.who.int/data/gho/publications/ world-health-statistics.